Anoctamin 6 抗体 (2nd Extracellular Loop)
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Quick Overview for Anoctamin 6 抗体 (2nd Extracellular Loop) (ABIN7042930)
抗原
See all Anoctamin 6 (ANO6) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Extracellular Loop, AA 487-500
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原理
- A Rabbit Polyclonal Antibody to Anoctamin-6 Channel
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - 12,14 amino acid residues identical
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产品特性
- Anti-Anoctamin-6 (extracellular) Antibody (ABIN7042930, ABIN7044137 and ABIN7044138) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, and live cell flow cytometry applications. It has been designed to recognize ANO6 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KLPKNINGTDPIQK, corresponding to amino acid residues 487-500 of human ANO6
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亚型
- IgG
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anti-Anoctamin 6 (ANO6) (AA 744-824) antibody
ANO6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 68-96), (N-Term) antibodyANO6 适用: 人 WB 宿主: 兔 Polyclonal RB42706 unconjugated
anti-Anoctamin 6 (ANO6) (AA 12-100) antibodyANO6 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 791-840) antibodyANO6 适用: 人, Cow, 兔, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (AA 480-529) antibodyANO6 适用: 人, 小鼠, 大鼠, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (Middle Region) antibodyANO6 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Anoctamin 6 (ANO6) (2nd Extracellular Loop), (AA 487-500) antibody (FITC)ANO6 适用: 人 FACS, LCI 宿主: 兔 Polyclonal FITC
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234747)
Blocking Peptide: (ABIN7234747)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Anoctamin 6 (ANO6)
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别名
- ANO6
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背景
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Synonyms: ANO6, Transmembrane protein 16F, TMEM16F, Small-conductance calcium-activated nonselective cation channel, SCAN channel
Description: Anoctamin-6 (ANO6, TMEM16F) is a member of the Anoctamin chloride channel family. This family includes 10 proteins: ANO1-ANO10 that are encoded by the conserved TMEM16A-K genes. Anoctamin-6 acts as calcium (Ca2+)-activated chloride (Cl-) channel. It generates an outwardly rectifying Cl- current when activated by a large increase in local intracellular Ca2+ concentrations1. ANO6 structure includes eight transmembrane domains and cytosolic amino- and carboxyl termini. There is a high sequence identity in the putative transmembrane domains and more divergent in other regions2,3.ANO6 has also been shown to operate as a Ca2+-activated phospholipid scramblase resulting in movement of phosphatidylserine from the inner to the outer leaflet of the plasma membrane bilayer. ANO6 is also involved in bone mineralization, cell volume regulation, cell proliferation and apoptosis1,2. ANO6 is expressed in cyst-forming epithelial cells together with ANO1.A mutation in the ANO6 gene is linked to Scott Syndrome, a rare inherited bleeding disorder, characterized by altered Ca2+-dependent platelet signaling with defective phosphatidylserine exposure and microparticle formation. Deletion of ANO6 in mice shows reduced skeleton size, skeletal deformities, and mineralization defects4,5.
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基因ID
- 196527
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NCBI登录号
- NM_001025356
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UniProt
- Q4KMQ2
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途径
- SARS-CoV-2 Protein Interactome
抗原
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