Anoctamin 5 抗体 (2nd Cytoplasmic Loop)
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Quick Overview for Anoctamin 5 抗体 (2nd Cytoplasmic Loop) (ABIN7042929)
抗原
See all Anoctamin 5 (ANO5) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- 2nd Cytoplasmic Loop, AA 532-544
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原理
- A Rabbit Polyclonal Antibody to Anoctamin-5 Channel
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交叉反应
- 小鼠, 大鼠
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预测反应
- Rat - identical, human - 12,13 amino acid residues identical
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产品特性
- Anti-Anoctamin-5 Antibody is directed against an epitope of mouse ANO5. Anti-Anoctamin-5 Antibody (ABIN7042929, ABIN7044135 and ABIN7044136) can be used in western blot analysis. It has been designed to recognize ANO5 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)TKMEIPRTHQEYE, corresponding to amino acid residues 532-544 of mouse ANO5
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亚型
- IgG
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anti-Anoctamin 5 (ANO5) (AA 792-819), (C-Term) antibody
ANO5 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB22028 unconjugated
anti-Anoctamin 5 (ANO5) (AA 798-828), (C-Term) antibodyANO5 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7234743)
Blocking Peptide: (ABIN7234743)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Anoctamin 5 (ANO5)
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别名
- ANO5
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背景
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Synonyms: ANO5, Transmembrane protein 16E, TMEM16E, GDD1, LGMD2L
Description: Anoctamins, also known as TMEM16, is a family of ten proteins involved in a variety of functions including phospholipid scrambling, ion transport and the regulation of other membrane proteins. ANO1 (Anoctamin-1), ANO2 and ANO5 function as Ca2+-activated Cl- channels (CaCCs) and play an important role in calcium dependent chloride secretion. All members of the Anoctamin family present high structural homology and consist of eight transmembrane domains and cytosolic N- and C-termini1.The ANO5 gene is widely distributed and expressed in bone, skeletal muscle, cardiac muscle, brain, lung and kidney and also in the mucosal layer of the GI tract and the skeletal muscle layer of the esophagus of mice2.In phylogenetic analysis ANO5 was found to be a close relative of ANO6. ANO6 has an association with phospholipid scramblase activity. Under both physiological and pathological conditions scramblase dissipates the normal asymmetry of the cell membrane by catalyzing the rapid externalization of phospholipids on the cell membrane and thus promoting apoptosis3.Recessive mutations in the ANO5 gene were found to be linked to limb-girdle muscular dystrophies type 2L (LGMD2L) and non-dysferlin Miyoshi myopathy4. LGMD2L is characterized by proximal weakness, asymmetric quadriceps femoris and atrophy of the biceps brachii muscle5.Mutations in the gene are also linked to the Gnathodiaphyseal dysplasia disease, an unusual generalized autosomal dominant disease. Patients with this syndrome show sclerosis of tubular bones, lesions of jawbones, an increased sensitivity for jaw infection and osteomyeletis and fragile bones6.
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基因ID
- 233246
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NCBI登录号
- NM_213599
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UniProt
- Q75UR0
抗原
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