ADRA2A 抗体 (Extracellular)
Quick Overview for ADRA2A 抗体 (Extracellular) (ABIN7042899)
抗原
See all ADRA2A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 7-20, Extracellular
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原理
- A Rabbit Polyclonal Antibody to α2A-Adrenergic Receptor
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特异性
- Extracellular, N-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,14 amino acid residues identical
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产品特性
- Anti-α2A-Adrenergic Receptor (extracellular) Antibody (ABIN7042899, ABIN7043918 and ABIN7043919) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize α2A-adrenoceptor from mouse, rat, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DAGNSSWNGTEAPG, corresponding to amino acid residues 7-20 of rat alpha2A-adrenoceptor
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亚型
- IgG
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anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 385-450) antibody
ADRA2A 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (Internal Region) antibodyADRA2A 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 240-380) antibodyADRA2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (Internal Region) antibodyVerified ADRA2A 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 331-380) antibodyADRA2A 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (C-Term) antibodyADRA2A 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 218-374) antibodyADRA2A 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 118-152) antibodyADRA2A 适用: 人 WB 宿主: 兔 Polyclonal RB53330 unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (AA 223-256) antibodyADRA2A 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB52053 unconjugated
anti-Alpha-2A Adrenergic Receptor (ADRA2A) (C-Term) antibodyADRA2A 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:250
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7234696)
Blocking Peptide: (ABIN7234696)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))
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别名
- ADRA2A
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背景
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Alpha-2A adrenoceptor, Alpha-2D adrenergic Receptor, α-2AAR, ADA2A, ADRA2A,Adrenergic receptors (also called adrenoceptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. Adrenergic receptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular N-terminus, and a cytoplasmic C- terminus.Adrenoceptors are divided into three types: α1, α2 and β-adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β31,2. Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1,2. In general, the pharmacological properties of each subtype are quite homogenous across different species. However, this is not the case for the α2A subtype which was first isolated from human platelets3. This subtype shows different pharmacological properties from that of mouse and rat. For this reason, until molecular techniques significantly advanced, it was believed that human α2A and that of mouse and rat (termed α2D) were two different subtypes. Today, it is accepted that these two subtypes are in fact one gene product and is generally termed α2A. One of the main differences between this subtype from the different organisms is its affinity for yohimbine and rauwolscine, rat and mouse α2A displays less affinity compared to human3,4.
Alternative names: alpha2A-Adrenergic Receptor, Alpha-2A adrenoceptor, Alpha-2D adrenergic Receptor, alpha-2AAR, ADA2A, ADRA2A -
基因ID
- 25083
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NCBI登录号
- NM_000681
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UniProt
- P22909
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途径
- EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Negative Regulation of Transporter Activity
抗原
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