Adhesion G-Protein Coupled Receptor G6 (ADGRG6) (AA 753-767), (Extracellular) 抗体
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Quick Overview for Adhesion G-Protein Coupled Receptor G6 (ADGRG6) (AA 753-767), (Extracellular) 抗体 (ABIN7042895)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 753-767, Extracellular
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原理
- A Rabbit Polyclonal Antibody to GPR126
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Anti-GPR126/ADGRG6 (extracellular) Antibody (ABIN7042895, ABIN7044451 and ABIN7044452) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. It has been designed to recognize ADGR6 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KDPVQIKIKHTRTQE, corresponding to amino acid residues 753 - 767 of mouse GPR126
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亚型
- IgG
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anti-Adhesion G-Protein Coupled Receptor G6 (ADGRG6) (AA 40-300) antibody
ADGRG6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7234653)
Blocking Peptide: (ABIN7234653)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Adhesion G-Protein Coupled Receptor G6 (ADGRG6)
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别名
- ADGRG6
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背景
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Adhesion G-Protein Coupled Receptor G6, G-Protein Coupled Receptor 126, Developmentally Regulated G-Protein-Coupled Receptor, DREG, Vascular Inducible G Protein-Coupled Receptor, VIGR,GPR126 is an adhesion G-protein coupled receptor, the second largest subgroup of GPCRs1. The defining characteristic of the adhesion GPCR family is their extraordinarily large N-terminal extracellular domain important to communicate with extracellular ligands and mediate adhesive functions2.GPR126 is implicated in an increasing number of developmental defects: skeletal defects, including shortened height, adolescent idiopathic scoliosis, arthrogryposis multiplex congenital, and periodontitis. Other studies reveal that GPR126 is essential for myelination of axons in the peripheral nervous system and the heart2.Known ligands of GPCR126 are type IV collagen (COLIV) in peripheral nerves and inner ear development, Laminin-211 during Schwann cell development, and prion protein in myelination3, suggesting that GPR126 could use different signaling pathways in different tissues4.
Alternative names: Adhesion G-Protein Coupled Receptor G6, G-Protein Coupled Receptor 126, Developmentally Regulated G-Protein-Coupled Receptor, DREG, Vascular Inducible G Protein-Coupled Receptor, VIGR -
基因ID
- 57211
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NCBI登录号
- NM_001032394
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UniProt
- Q86SQ4
抗原
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