ADCY3 抗体 (Extracellular)
Quick Overview for ADCY3 抗体 (Extracellular) (ABIN7042892)
抗原
See all ADCY3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 285-299, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Adenylate Cyclase Type III
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特异性
- 3rd extracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Adenylate Cyclase 3 (AC3) (extracellular) Antibody (ABIN7042892, ABIN7043932 and ABIN7043933) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry and live cell imaging applications. The antibody recognizes an extracellular epitope and thus is ideal for detecting ADCY3 in living cells. It has been designed to recognize ADCY3 from human, rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KHVADEMLKDMKKDE, corresponding to amino acid residues 285-299 of rat ADCY3
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亚型
- IgG
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anti-Adenylate Cyclase 3 (ADCY3) (AA 501-736) antibody
ADCY3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) antibodyADCY3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (C-Term) antibodyADCY3 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (AA 651-750) antibodyADCY3 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (AA 1125-1144) antibodyADCY3 适用: 大鼠, 小鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adenylate Cyclase 3 (ADCY3) (AA 1-80) antibodyADCY3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: LCI
Negative Control: (ABIN7234646)
Blocking Peptide: (ABIN7234646)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- ADCY3 (Adenylate Cyclase 3 (ADCY3))
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别名
- ADCY3
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背景
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Adenylate cyclase type 3, Adenylate cyclase type III, AC-III, ATP pyrophosphate-lyase 3, Adenylate cyclase olfactive type, Adenylyl cyclase 3, ADCY3,Adenylyl cyclases (ACs) are a family of enzymes that synthesize cAMP, upon stimulation. cAMP is an important second messenger, which regulates carbohydrate, lipid, protein, and nucleic acid metabolism as well as synaptic transmission, ion channel function, and transcription in neurons1. There are nine closely related isoforms of ACs (AC1-9) in mammals. All AC isoforms share a primary structure consisting of two hydrophobic regions which comprise six transmembrane helices and three large cytoplasmic domains. The basic catalytic unit of a membrane-bound AC molecule consists of the C1a and C2 domains. The N-terminus domains of ACs are highly variable, and might play a regulatory role2.Adenylyl cyclase type 3 (AC3) is widely expressed in the olfactory tissue, human cell line HEK-293, bovine brain, spinal cord, adrenal medulla, adrenal cortex, heart atrium, aorta, lung and retina3.Several studies have suggested that AC3 may play an important role in the regulation of glucose metabolism and body weight. It was found that overexpression of AC3 mRNA is involved in pathophysiological metabolic processes, such as type 2 diabetes4. In addition, a recent study demonstrated the association of AC3 with gastric cancer as well as its tumorigenic potentials5.Furthermore, AC3-knockout mice showed peripheral and behavioral anosmia6.
Alternative names: Adenylate Cyclase 3 (AC3), Adenylate cyclase type 3, Adenylate cyclase type III, AC-III, ATP pyrophosphate-lyase 3, Adenylate cyclase olfactive type, Adenylyl cyclase 3, ADCY3 -
基因ID
- 64508
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NCBI登录号
- NM_001320613
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UniProt
- P21932
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途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
抗原
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