-
- 抗原
- TCR, Cbeta1
- 适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- 非结合性
- 应用范围
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
- 特异性
- The mouse monoclonal antibody JOVI.1 recognizes an extracellular epitope on TCR Cbeta1 (TRBC1).
- 纯化方法
- Purified by protein-A affinity chromatography.
- 免疫原
- thymus, spleen, and mesenteric lymph nodes isolated from a mouse transgenic for human TCR Vbeta3Cbeta1
- 克隆位点
- JOVI-1
- 亚型
- IgG2a kappa
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anti-TCR, Cbeta1 antibody (FITC)
适用: 人 FACS 宿主: 小鼠 Monoclonal JOVI-1 FITC
anti-TCR, Cbeta1 antibody (APC)适用: 人 FACS 宿主: 小鼠 Monoclonal JOVI-1 APC
anti-TCR, Cbeta1 antibody (PE)适用: 人 FACS 宿主: 小鼠 Monoclonal JOVI-1 PE
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- 应用备注
- Flow cytometry: Recommended dilution: 2-6 μg/mL
- 限制
- 仅限研究用
-
- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
-
- 抗原
- TCR, Cbeta1
- 别名
- TCR Cbeta1
- 背景
- T cell receptor beta constant 1,Alpha-beta T cell receptors (TCRs) are antigen specific receptors, which are essential to the immune response and are present on the cell surface of T lymphocytes. They recognize peptide-loaded major histocompatibility complexes (pMHCs), that are displayed by antigen presenting cells (APCs). Binding of alpha-beta TCR to pMHC initiates TCR-CD3 clustering on the cell surface and intracellular activation of LCK, that phosphorylates the ITAM motifs of CD3gamma, CD3delta, CD3epsilon and CD3zeta, enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium signaling, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NFkappaB (NF-kB) pathways, leading to the mobilization of transcription factors, that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated by V-D-J-C rearrangements. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MHC restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TCRs with the pMHCs shapes TCR structural and functional avidity.,TCRCB1, TRBC1
- 基因ID
- 28639
- UniProt
- P01850
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