STRA13 抗体
This anti-STRA13 antibody is a 兔 多克隆 antibody detecting STRA13 in WB. Suitable for 人.
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Quick Overview for STRA13 抗体 (ABIN7264936)
抗原
See all STRA13 抗体
STRA13
(Stimulated By Retinoic Acid 13 Homolog (STRA13))
适用
人
宿主
兔
克隆类型
多克隆
标记
This STRA13 antibody is un-conjugated
应用范围
Western Blotting (WB)
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human STRA13 (NP_659435.2).
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亚型
- IgG
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anti-Stimulated By Retinoic Acid 13 Homolog (STRA13) (N-Term) antibody
STRA13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Stimulated By Retinoic Acid 13 Homolog (STRA13) (AA 1-63) antibodySTRA13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
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别名
- STRA13
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背景
- DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
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分子量
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Observed_MW: 14 kDa
Calculated_MW: 6 kDa/7 kDa/8 kDa
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基因ID
- 201254
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UniProt
- A8MT69
抗原
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