EXOSC4 抗体
Quick Overview for EXOSC4 抗体 (ABIN7264747)
抗原
See all EXOSC4 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human EXOSC4 (NP_061910.1).
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亚型
- IgG
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anti-Exosome Component 4 (EXOSC4) (AA 1-100) antibody
EXOSC4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F10 unconjugated
anti-Exosome Component 4 (EXOSC4) (N-Term) antibodyEXOSC4 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 兔, 非洲爪蟾, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 4 (EXOSC4) (N-Term) antibodyEXOSC4 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 4 (EXOSC4) antibodyEXOSC4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 4 (EXOSC4) (N-Term) antibodyEXOSC4 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 兔, Saccharomyces cerevisiae, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 4 (EXOSC4) (AA 1-245) antibodyEXOSC4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Exosome Component 4 (EXOSC4) (AA 1-245) antibodyEXOSC4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- EXOSC4 (Exosome Component 4 (EXOSC4))
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别名
- EXOSC4
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背景
- Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.
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分子量
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Observed_MW: 26 kDa
Calculated_MW: 26 kDa
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基因ID
- 54512
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UniProt
- Q9NPD3
抗原
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