HIRA 抗体
Quick Overview for HIRA 抗体 (ABIN7264499)
抗原
See all HIRA 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human HIRA (NP_003316.3).
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亚型
- IgG
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应用备注
- WB 1:500-1:2000 IHC 1:100-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))
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别名
- HIRA
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背景
- This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
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分子量
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Observed_MW: 112 kDa
Calculated_MW: 89 kDa/111 kDa
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基因ID
- 7290
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UniProt
- P54198
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途径
- Chromatin Binding
抗原
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