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AVPR2 抗体

AVPR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7263913
发货至: 中国
  • 抗原 See all AVPR2 抗体
    AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))
    适用
    • 33
    • 24
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 55
    • 1
    克隆类型
    • 56
    多克隆
    标记
    • 28
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
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    This AVPR2 antibody is un-conjugated
    应用范围
    • 34
    • 21
    • 14
    • 14
    • 7
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein of human AVPR2 (NP_000045.1).
    亚型
    IgG
    Top Product
    Discover our top product AVPR2 Primary Antibody
  • 应用备注
    WB 1:500-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))
    别名
    AVPR2 (AVPR2 产品)
    别名
    AVPR2 antibody, ADHR antibody, DI1 antibody, DIR antibody, DIR3 antibody, NDI antibody, V2R antibody, ND1 antibody, VPV2R antibody, arginine vasopressin receptor 2 antibody, AVPR2 antibody, Avpr2 antibody
    背景
    This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
    分子量

    Observed_MW: 46 kDa

    Calculated_MW: 33 kDa/40 kDa

    基因ID
    554
    UniProt
    P30518
    途径
    cAMP Metabolic Process
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