AF4 抗体
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北京 101111
Quick Overview for AF4 抗体 (ABIN7262837)
抗原
适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human AFF1 (NP_001160165.1).
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亚型
- IgG
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anti-AF4/FMR2 Family, Member 1 (AFF1) (AA 1181-1210) antibody
AFF1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-AF4/FMR2 Family, Member 1 (AFF1) (N-Term) antibodyAFF1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-AF4/FMR2 Family, Member 1 (AFF1) (AA 1-183) antibodyAFF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-AF4/FMR2 Family, Member 1 (AFF1) (N-Term) antibodyAFF1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
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别名
- AFF1
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背景
- This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants.
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基因ID
- 4299
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UniProt
- P51825
抗原
-
