Arachidonate 15-lipoxygenaseis anenzymethat in humans is encoded by theALOX15gene. The ALOX15 gene maps to 17p13.3 in close proximity to the tumor-suppressor gene TP53. The ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid.