PIKFYVE 抗体
Quick Overview for PIKFYVE 抗体 (ABIN7011299)
抗原
See all PIKFYVE 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human PIKFYVE (NP_689884.1).
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亚型
- IgG
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anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) (AA 342-451) antibody
PIKFYVE 适用: 人 ELISA, WB, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 6C7 unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) (AA 1819-2098) antibodyPIKFYVE 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) (AA 342-451) antibodyPIKFYVE 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) antibodyPIKFYVE 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) (AA 1531-1561) antibodyPIKFYVE 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB5311 unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) (N-Term) antibodyPIKFYVE 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) antibodyPIKFYVE 适用: Various Species WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) (AA 1-451) antibodyPIKFYVE 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) (N-Term) antibodyPIKFYVE 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) (AA 1680-1931) antibodyPIKFYVE 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000 IHC 1:50-1:100 IF 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))
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别名
- PIKFYVE
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背景
- Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve, also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD), an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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分子量
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Observed_MW: 280 kDa
Calculated_MW: 50 kDa/51 kDa/61 kDa/237 kDa
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基因ID
- 200576
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UniProt
- Q9Y2I7
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途径
- Inositol Metabolic Process
抗原
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