Geminin 抗体
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- 抗原 See all Geminin (GMNN) 抗体
- Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Geminin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein of human GMNN (NP_056979.1).
- 亚型
- IgG
- Top Product
- Discover our top product GMNN Primary Antibody
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- 应用备注
- WB 1:500-1:2000 IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))
- 别名
- GMNN (GMNN 产品)
- 背景
- This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
- 分子量
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Observed_MW: 24 kDa
Calculated_MW: 23 kDa
- 基因ID
- 51053
- UniProt
- O75496
- 途径
- EGFR Signaling Pathway, DNA Replication
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