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AMPK alpha 抗体

SNF1A 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7259664
发货至: 中国
  • 抗原 See all AMPK alpha (SNF1A) 抗体
    AMPK alpha (SNF1A) (SNF1A/AMP-Activated Protein Kinase (SNF1A))
    适用
    • 13
    • 8
    • 8
    • 3
    • 2
    • 2
    人, 小鼠, 大鼠
    宿主
    • 12
    • 1
    克隆类型
    • 12
    • 1
    多克隆
    标记
    • 13
    This AMPK alpha antibody is un-conjugated
    应用范围
    • 13
    • 10
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of human PRKAA1/PRKAA2.
    亚型
    IgG
    Top Product
    Discover our top product SNF1A Primary Antibody
  • 应用备注
    IF 1:50-1:100
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    AMPK alpha (SNF1A) (SNF1A/AMP-Activated Protein Kinase (SNF1A))
    别名
    PRKAA1/PRKAA2 (SNF1A 产品)
    别名
    AMPK antibody, AMPK2 antibody, AMPKa2 antibody, PRKAA antibody, protein kinase AMP-activated catalytic subunit alpha 2 antibody, PRKAA2 antibody
    背景
    The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed./The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
    基因ID
    5562, 5563
    UniProt
    Q13131, P54646
    途径
    Warburg Effect
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