Titin 抗体
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北京 101111
Quick Overview for Titin 抗体 (ABIN7259346)
抗原
See all Titin (TTN) 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant Protein of human TTN.
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亚型
- IgG
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anti-Titin (TTN) (AA 1-110) antibody
TTN 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2B3 unconjugated
anti-Titin (TTN) (AA 1-110) antibodyTTN 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 7D3 unconjugated
anti-Titin (TTN) (AA 2670-2703) antibodyTTN 适用: 人, 大鼠, 小鼠 ELISA, FACS, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Titin (TTN) (AA 33779-34025) antibodyTTN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Titin (TTN) (AA 5398-5604) antibodyTTN 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Titin (TTN) (AA 7169-7203), (N-Term) antibodyTTN 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB49137 unconjugated
anti-Titin (TTN) (AA 1-110) antibodyTTN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F12 unconjugated
anti-Titin (TTN) (AA 33779-34025) antibodyTTN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Titin (TTN) (AA 1-110) antibodyTTN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- IF 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Titin (TTN)
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别名
- TTN
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背景
- This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.
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基因ID
- 7273
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UniProt
- Q8WZ42
抗原
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