UNC13B 抗体
Quick Overview for UNC13B 抗体 (ABIN7258666)
抗原
See all UNC13B 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of human UNC13B (NP_006368.3).
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亚型
- IgG
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应用备注
- WB 1:500-1:2000 IF 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- UNC13B (Unc-13 Homolog B (UNC13B))
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别名
- UNC13B
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背景
- This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
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分子量
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Observed_MW: 210 kDa
Calculated_MW: 180 kDa/182 kDa
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基因ID
- 10497
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UniProt
- O14795
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途径
- Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
抗原
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