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F13A1 抗体

F13A1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7257986
发货至: 中国
  • 抗原 See all F13A1 抗体
    F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
    适用
    • 77
    • 7
    • 6
    • 3
    • 3
    人, 小鼠, 大鼠
    宿主
    • 46
    • 31
    • 3
    • 1
    克隆类型
    • 49
    • 32
    多克隆
    标记
    • 50
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This F13A1 antibody is un-conjugated
    应用范围
    • 46
    • 45
    • 30
    • 30
    • 22
    • 19
    • 15
    • 8
    • 7
    • 3
    • 3
    • 3
    • 2
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    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein of human F13A1 (NP_000120.2).
    亚型
    IgG
    Top Product
    Discover our top product F13A1 Primary Antibody
  • 应用备注
    WB 1:500-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
    别名
    F13A1 (F13A1 产品)
    别名
    F13a antibody, f13a1 antibody, wu:fo83d04 antibody, zgc:153334 antibody, F13A1 antibody, F13A antibody, 1200014I03Rik antibody, AI462306 antibody, coagulation factor XIII A1 chain antibody, coagulation factor XIII, A1 polypeptide b antibody, coagulation factor XIII A chain antibody, coagulation factor XIII, A1 subunit antibody, F13a1 antibody, f13a1b antibody, F13A1 antibody
    背景
    This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
    分子量

    Observed_MW: 83 kDa

    Calculated_MW: 83 kDa

    基因ID
    2162
    UniProt
    P00488
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