SETDB1 抗体
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北京 101111
Quick Overview for SETDB1 抗体 (ABIN7253431)
抗原
See all SETDB1 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Antigen affinity purification
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免疫原
- Fusion protein of human SETDB1
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亚型
- IgG
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anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibody
SETDB1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4A3 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibodySETDB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) antibodySETDB1 适用: 人, 小鼠, 猴 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 5H6A12 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1-397) antibodySETDB1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225) antibodySETDB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-100) antibodySETDB1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1193-1225), (C-Term) antibodySETDB1 适用: 人 WB 宿主: 兔 Polyclonal RB5748 unconjugated
anti-SET Domain, Bifurcated 1 (SETDB1) (AA 1050-1075) antibodySETDB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC 1:50-1:300, ELISA 1:5000-1:10000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.08 mg/mL
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缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SETDB1 (SET Domain, Bifurcated 1 (SETDB1))
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别名
- SETDB1
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背景
- SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.
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UniProt
- Q15047
抗原
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