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CAMSAP3 抗体

CAMSAP3 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7245497
发货至: 中国
  • 抗原 See all CAMSAP3 抗体
    CAMSAP3 (Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 (CAMSAP3))
    适用
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    人, 小鼠
    宿主
    • 21
    克隆类型
    • 21
    多克隆
    标记
    • 4
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    This CAMSAP3 antibody is un-conjugated
    应用范围
    ELISA, Immunohistochemistry (IHC)
    产品特性
    Polyclonal Antibody
    纯化方法
    Antigen affinity purification
    免疫原
    Synthetic peptide of human CAMSAP3
    亚型
    IgG
  • 应用备注
    IHC 1:100-1:300, ELISA 1:5000-1:10000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.56 mg/mL
    缓冲液
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    CAMSAP3 (Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 (CAMSAP3))
    别名
    CAMSAP3 (CAMSAP3 产品)
    别名
    KIAA1543 antibody, NEZHA antibody, 2310057J16Rik antibody, Kiaa1543 antibody, Nezha antibody, calmodulin regulated spectrin associated protein family member 3 antibody, calmodulin regulated spectrin-associated protein family, member 3 antibody, CAMSAP3 antibody, Camsap3 antibody
    背景
    Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391).
    UniProt
    Q9P1Y5
    途径
    Cell-Cell Junction Organization, Maintenance of Protein Location
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