CAMSAP3 抗体
This anti-CAMSAP3 antibody is a 兔 多克隆 antibody detecting CAMSAP3 in ELISA 和 IHC. Suitable for 人 和 小鼠.
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Quick Overview for CAMSAP3 抗体 (ABIN7245497)
抗原
See all CAMSAP3 抗体
CAMSAP3
(Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 (CAMSAP3))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This CAMSAP3 antibody is un-conjugated
应用范围
ELISA, Immunohistochemistry (IHC)
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产品特性
- Polyclonal Antibody
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纯化方法
- Antigen affinity purification
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免疫原
- Synthetic peptide of human CAMSAP3
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亚型
- IgG
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anti-Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 (CAMSAP3) (AA 103-131), (N-Term) antibody
CAMSAP3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB24779 unconjugated
anti-Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 (CAMSAP3) (C-Term) antibodyCAMSAP3 适用: 人, 小鼠, Cow, 犬, 豚鼠, 马, Pig, 兔, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC 1:100-1:300, ELISA 1:5000-1:10000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.56 mg/mL
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缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- CAMSAP3 (Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 (CAMSAP3))
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别名
- CAMSAP3
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背景
- Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391).
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UniProt
- Q9P1Y5
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途径
- Cell-Cell Junction Organization, Maintenance of Protein Location
抗原
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