ACER1 抗体
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北京 101111
Quick Overview for ACER1 抗体 (ABIN7244708)
抗原
See all ACER1 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Antigen affinity purification
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免疫原
- Synthetic peptide of human ACER1
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亚型
- IgG
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anti-Alkaline Ceramidase 1 (ACER1) (Internal Region) antibody
ACER1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (Internal Region) antibodyACER1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (AA 141-190) antibodyACER1 适用: 人, 猴, Cow, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 1 (ACER1) (C-Term) antibodyACER1 适用: 人, 大鼠, Cow, 豚鼠, 兔, 犬, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC 1:40-1:200, ELISA 1:5000-1:10000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.2 mg/mL
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缓冲液
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- ACER1 (Alkaline Ceramidase 1 (ACER1))
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别名
- ACER1
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背景
- ACER1 (Alkaline Ceramidase 1) is a Protein Coding gene. Diseases associated with ACER1 include Corneal Dystrophy, Posterior Amorphous. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and dihydroceramidase activity. An important paralog of this gene is ACER2.Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine.
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UniProt
- Q8TDN7
抗原
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