PRPS1/2/1L1 抗体
This 兔 多克隆 antibody specifically detects PRPS1/2/1L1 in IHC, ELISA 和 WB. It exhibits reactivity toward 人 和 小鼠.
产品编号 ABIN7242494
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for PRPS1/2/1L1 抗体 (ABIN7242494)
抗原
PRPS1/2/1L1
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
-
-
产品特性
- Polyclonal Antibody
-
纯化方法
- Affinity purification
-
免疫原
- Synthetic peptide of human PRPS1/2/1L1
-
亚型
- IgG
-
-
-
-
应用备注
- WB 1:500-1:2000, IHC 1:25-1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.4 mg/mL
-
缓冲液
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- PRPS1/2/1L1
-
别名
- PRPS1/2/PRPS1L1
-
背景
- PRPS (phosphoribosyl pyrophosphate synthetase) proteins catalyze the synthesis of phosphoribosyl pyrophosphate (PRPP). Three human PRPS isoforms exist and are encoded by three different genes. PRPS1 and PRPS2 (also known as PRS1 and PRS2, respectively) are ubiquitously expressed, while PRPS3 (also known as PRPS1L1) is specific to the testis. PRPP is an important substrate synthesized from MgATP and ribose-5-phosphate in a reaction that requires inorganic phosphate and magnesium as a cofactor. PRPP is essential in the synthesis of nearly all nucleotides, implying that PRPS1/2 play an important role in nucleotide biosynthesis and purine metabolism. A mutation in the gene encoding PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproduction of purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5).
-
分子量
- 35 kDa
-
UniProt
- P60891, P11908, P21108
抗原
-
You are here:
