RNF144B 抗体
Quick Overview for RNF144B 抗体 (ABIN7241528)
抗原
See all RNF144B 抗体适用
宿主
克隆类型
标记
应用范围
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein of human RNF144B
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亚型
- IgG
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anti-Ring Finger Protein 144B (RNF144B) (AA 1-101) antibody
RNF144B 适用: 人 WB, ELISA, IF, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4F1 unconjugated
anti-Ring Finger Protein 144B (RNF144B) (AA 1-100) antibodyRNF144B 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4F1 unconjugated
anti-Ring Finger Protein 144B (RNF144B) (AA 1-302) antibodyRNF144B 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 144B (RNF144B) (Internal Region) antibodyRNF144B 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 144B (RNF144B) (AA 215-264) antibodyRNF144B 适用: 人, 小鼠, Cow, 犬, 豚鼠, 马, 兔, 大鼠, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:200-1:1000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.4 mg/mL
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缓冲液
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- RNF144B (Ring Finger Protein 144B (RNF144B))
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别名
- p53RFP
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背景
- P53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
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分子量
- 34 kDa
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UniProt
- Q7Z419
抗原
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