NUAK1 抗体
Our Local Distributor
北京 101111
Quick Overview for NUAK1 抗体 (ABIN7238549)
抗原
See all NUAK1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
产品特性
- Polyclonal Antibody
-
纯化方法
- Affinity purification
-
免疫原
- Synthetic peptide of human NUAK1
-
亚型
- IgG
-
-
-
-
应用备注
- IHC 1:25-1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.6 mg/mL
-
缓冲液
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
-
别名
- NUAK1
-
背景
- NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
-
NCBI登录号
- NP_055655
-
UniProt
- O60285
抗原
-