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Deoxyuridine Triphosphatase (DUT) 抗体

This anti- antibody is a 兔 多克隆 antibody detecting in WB, IHC 和 ELISA. Suitable for 人 和 大鼠.
产品编号 ABIN7237970
发货至: 中国

Quick Overview for Deoxyuridine Triphosphatase (DUT) 抗体 (ABIN7237970)

抗原

See all Deoxyuridine Triphosphatase (DUT) 抗体
Deoxyuridine Triphosphatase (DUT)

适用

  • 80
  • 33
  • 17
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
人, 大鼠

宿主

  • 77
  • 2
  • 1

克隆类型

  • 78
  • 2
多克隆

标记

  • 30
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
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  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
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  • 1
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非结合性

应用范围

  • 63
  • 26
  • 26
  • 22
  • 17
  • 15
  • 8
  • 6
  • 4
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • 产品特性

    Polyclonal Antibody

    纯化方法

    Affinity purification

    免疫原

    Synthetic peptide of human DUT

    亚型

    IgG
  • 应用备注

    WB 1:200-1:1000, IHC 1:10-1:50

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    Deoxyuridine Triphosphatase (DUT)

    别名

    DUT

    背景

    This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

    分子量

    27 kDa

    NCBI登录号

    NP_001939

    UniProt

    P33316
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