HSP40-4 抗体
The 兔 多克隆 anti-HSP40-4 antibody is suitable to detect HSP40-4 in samples from 人, 小鼠 和 大鼠. It has been validated for IHC, ELISA 和 WB.
产品编号 ABIN7237214
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for HSP40-4 抗体 (ABIN7237214)
抗原
HSP40-4
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
应用范围
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
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产品特性
- Polyclonal Antibody
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein of human DNAJA1
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亚型
- IgG
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应用备注
- WB 1:500-1:2000, IHC 1:100-1:300
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- HSP40-4
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背景
- DnaJ-like proteins interact with HSP 70 Molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
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分子量
- 45 kDa
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UniProt
- P31689
抗原
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