CDK4 抗体
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- 抗原 See all CDK4 抗体
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CDK4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 产品特性
- Polyclonal Antibody
- 纯化方法
- Antigen Affinity Purification
- 免疫原
- Recombinant Human Cyclin-dependent kinase 4 protein
- 亚型
- IgG
- Top Product
- Discover our top product CDK4 Primary Antibody
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- 应用备注
- WB 1:1000-1:2000 IHC 1:100-1:300
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.05 % Proclin300 and 50 % glycerol, pH 7.4.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
- 别名
- CDK4 (CDK4 产品)
- 背景
- The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
- 分子量
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Observed_MW: 21 kDa
Calculated_MW: 34,21 kDa
- UniProt
- P11802
- 途径
- Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size
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