SARS-CoV-2 Spike S1 抗体 (RBD)
Quick Overview for SARS-CoV-2 Spike S1 抗体 (RBD) (ABIN6992312)
抗原
See all SARS-CoV-2 Spike S1 抗体片段
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- RBD
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纯化方法
- SARS-CoV-2 (COVID-19) S1 RBD Antibody [T4P3-B5] is affinity chromatography purified via Nickel column. Antibody is supplied as a His-tagged purified protein. It also contains a myc-tag for detection.
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免疫原
- SARS-CoV-2 S protein RBD containing C-terminal His Tag. The protein was expressed in human 293 cells (HEK293). It contains amino acids Arg 319 - Lys 537.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- SARS-CoV-2 (COVID-19) S1 RBD Antibody [T4P3-B5] Antibody is supplied in PBS.
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储存条件
- -20 °C
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储存方法
- SARS-CoV-2 (COVID-19) S1 RBD antibody should be stored in working aliquots at -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- SARS-CoV-2 Spike S1
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别名
- SARS-CoV-2 S1
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物质类
- Viral Protein
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背景
- Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).
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基因ID
- 43740568
抗原
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