DIRAS3 抗体 (C-Term)
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Quick Overview for DIRAS3 抗体 (C-Term) (ABIN6992120)
抗原
See all DIRAS3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- DIRAS3 antibody is human specific.
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纯化方法
- DIRAS3 antibody is affinity chromatography purified via peptide column.
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免疫原
- DIRAS3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DIRAS3. The immunogen is located within the last 50 amino acids of DIRAS3.
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亚型
- IgG
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anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) antibody
DIRAS3 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23150 unconjugated
anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) (AA 130-229) antibodyDIRAS3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) (C-Term) antibodyDIRAS3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) (AA 130-229) antibodyDIRAS3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G4 unconjugated
anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) (AA 131-229) antibodyDIRAS3 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) (AA 1-229) antibodyDIRAS3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) (AA 1-229) antibodyDIRAS3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) antibodyDIRAS3 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1218 unconjugated
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应用备注
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DIRAS3 antibody can be used for detection of DIRAS3 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- DIRAS3 antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- DIRAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))
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别名
- DIRAS3
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背景
- DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).
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分子量
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Predicted: 25 kDa
Observed: 24 kDa -
基因ID
- 9077
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NCBI登录号
- NP_004666
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UniProt
- O95661
抗原
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