Sestrin 2 抗体 (AA 220-270)
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- 抗原 See all Sestrin 2 (SESN2) 抗体
- Sestrin 2 (SESN2)
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抗原表位
- AA 220-270
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Sestrin 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- SESTRIN2 antibody is human, mouse and rat reactive. At least two isoforms of SESTRIN2 are known to exist, this antibody will detect both isoforms. SESTRIN2 antibody is predicted to not cross-react with SESTRIN1.
- 纯化方法
- SESTRIN2 antibody is affinity chromatography purified via peptide column.
- 免疫原
- SESTRIN2 antibody was raised against a 19 amino acid peptide near the center of human SESTRIN2. The immunogen is located within amino acids 220 - 270 of SESTRIN2.
- 亚型
- IgG
- Top Product
- Discover our top product SESN2 Primary Antibody
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anti-Sestrin 2 (SESN2) (AA 1-480) antibody
SESN2 适用: 人 WB, ELISA, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Sestrin 2 (SESN2) (AA 1-480) antibodySESN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Sestrin 2 (SESN2) (AA 41-480) antibodySESN2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 42-61) antibodySESN2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 1-480) antibodySESN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 268-317) antibodySESN2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (N-Term) antibodySESN2 适用: 人, Cow, 犬, 豚鼠, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 211-480) antibodySESN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 283-311) antibodySESN2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB18603 unconjugated
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- 应用备注
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SESTRIN2 antibody can be used for detection of SESTRIN2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- SESTRIN2 antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- SESTRIN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- 抗原
- Sestrin 2 (SESN2)
- 别名
- SESTRIN2 (SESN2 产品)
- 别名
- HI95 antibody, SES2 antibody, SEST2 antibody, Ses2 antibody, MGC81239 antibody, SESN2 antibody, sestrin-2 antibody, hi95 antibody, ses2 antibody, sest2 antibody, Sestrin-2 antibody, RGD1566319 antibody, sestrin 2 antibody, sestrin 2 L homeolog antibody, SESN2 antibody, Sesn2 antibody, sesn2.L antibody, sesn2 antibody
- 背景
- SESTRIN2, also known as Hi95, is a member of the sestrin family of PA26-related proteins and is induced following DNA damage or oxidative stress (1). SESTRIN2 and the related protein SESTRIN1 interact with the NRF2 suppressor KEAP1, the autophagy substrate p62 and the ubiquitin ligase RBX1 to protect cells against oxidative stress by activating NRF2 and promoting the p62-dependent autophagic degradation of KEAP1 (2). SESTRIN2 also negatively regulates TOR signaling by activating AMP-activated protein kinase (AMPK) and TSC2 phosphorylation (3), thereby protecting cells against energetic stress-induced death (4).
- 分子量
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Predicted: 54 kDa
Observed: 53 kDa - 基因ID
- 83667
- NCBI登录号
- NP_113647
- UniProt
- P58004
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