KIRREL2 antibody is human, mouse and rat reactive. At least five isoforms are are known to exist. This antibody is predicted to not cross-react with other members of the KIRREL protein family.
纯化方法
KIRREL2 antibody is affinity chromatography purified via peptide column.
免疫原
KIRREL2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KIRREL2. The immunogen is located within amino acids 550 - 600 of KIRREL2.
KIRREL2
适用: 大鼠
WB, IF (cc), IF (p)
宿主: 兔
Polyclonal
Alexa Fluor 555
应用备注
KIRREL2 antibody can be used for detection of KIRREL2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
KIRREL2 antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
KIRREL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
抗原
KIRREL2
(Kin of IRRE Like 2 (Drosophila) (KIRREL2))
nlg1 antibody, neph3 antibody, filtrin antibody, FILTRIN antibody, NEPH3 antibody, NLG1 antibody, C330019F22Rik antibody, cb33 antibody, kirrel3 antibody, sb:cb33 antibody, si:dkey-29g23.1 antibody, wu:fb74e02 antibody, kirre like nephrin family adhesion molecule 2 antibody, kin of IRRE like 2 (Drosophila) antibody, kirre like nephrin family adhesion molecule 3, like antibody, kirrel2 antibody, KIRREL2 antibody, Kirrel2 antibody, kirrel3l antibody
背景
KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1). KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2). KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4). Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5).