USP25 抗体 (AA 470-520)
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Quick Overview for USP25 抗体 (AA 470-520) (ABIN6991995)
抗原
See all USP25 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 470-520
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特异性
- USP25 antibody is human and mouse reactive. Multiple isoforms of USP25 are known to exist.
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纯化方法
- USP25 antibody is affinity chromatography purified via peptide column.
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免疫原
- USP25 antibody was raised against a 17 amino acid peptide near the center of human USP25. The immunogen is located within amino acids 470 - 520 of USP25.
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亚型
- IgG
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应用备注
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USP25 antibody can be used for detection of USP25 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- USP25 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- USP25 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- USP25 (Ubiquitin Specific Peptidase 25 (USP25))
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别名
- USP25
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背景
- USP25 (ubiquitin specific peptidase 25), also known as USP21, belongs to the peptidase C19 family and is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response (1). It contains one UBA-like domain and two UIM (ubiquitin-interacting motif) repeats. Due to alternative splicing events, USP25 is expressed as two short, ubiquitously expressed isoforms and one long, muscle-specific isoform (2). The long isoform of USP25 (USP25m) is upregulated in myogenesis and is implicated in regulation of muscular differentiation and function. USP25 is a deubiquitinating enzyme (DUB) that negatively regulates IL-17-triggered signaling (3,4).
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分子量
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Predicted: 116 kDa
Observed: 105 kDa -
基因ID
- 29761
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NCBI登录号
- NP_037528
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UniProt
- Q9UHP3
抗原
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