SUZ12 抗体 (AA 400-450)
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北京 101111
Quick Overview for SUZ12 抗体 (AA 400-450) (ABIN6991970)
抗原
See all SUZ12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 400-450
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特异性
- SUZ12 antibody is human specific.
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纯化方法
- SUZ12 antibody is affinity chromatography purified via peptide column.
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免疫原
- SUZ12 antibody was raised against a 19 amino acid peptide near the center of human SUZ12. The immunogen is located within amino acids 400 - 450 of SUZ12.
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亚型
- IgG
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应用备注
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SUZ12 antibody can be used for detection of SUZ12 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- SUZ12 antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- SUZ12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12))
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别名
- SUZ12
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背景
- The Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation and oncogenesis (1). SUZ12 (suppressor of zeste 12) is a 90 - 95 kDa member of the polycomb group of transcriptional regulators (2). It is part of a transcription repression complex termed PRC2 (Polycomb repressive complex 2) that methylates histones in the nucleus, resulting in homeotic (pattern-inducing) gene silencing. It contains one C2H2-type zinc finger region and a C-terminal VEFS-box (3,4). SUZ12 is overexpressed in breast and colon cancer. SUZ12 may be a cause of endometrial stromal tumors (5).
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分子量
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Predicted: 81 kDa
Observed: 96 kDa -
基因ID
- 23512
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NCBI登录号
- NP_056170
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UniProt
- Q15022
抗原
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