TRIM33 抗体 (AA 580-630)
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北京 101111
Quick Overview for TRIM33 抗体 (AA 580-630) (ABIN6991872)
抗原
See all TRIM33 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 580-630
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特异性
- TRIM33 antibody is human, mouse and rat reactive. At least two isoforms of TRIM33 are known to exist.
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纯化方法
- TRIM33 Antibody is affinity chromatography purified via peptide column.
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免疫原
- TRIM33 antibody was raised against an 18 amino acid peptide near the center of human TRIM33. The immunogen is located within amino acids 580 - 630 of TRIM33.
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亚型
- IgG
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应用备注
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TRIM33 antibody can be used for detection of TRIM33 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TRIM33 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TRIM33 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- TRIM33 (Tripartite Motif Containing 33 (TRIM33))
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别名
- TRIM33
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背景
- TRIM33 Antibody: TRIM24 (TIF1alpha), TRIM28 (TIF1beta), and TRIM33 (TIF1gamma) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors (1-2). The structure of TRIM33 is similar to TRIM24 and TRIM28, exhibiting multiple domains (RING finger, coiled coil, B boxes, PHD/TTC, and bromodomain) (3). TRIM33 functions in cell differentiation and development, playing a role in differentiation of hematopoietic cells (3). It interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGF-beta (4). It acts as an E3 ubiquitin-protein ligase and promotes SMAD4 ubiquitination (5).
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分子量
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Predicted: 70, 124 kDa
Observed: 70 kDa -
基因ID
- 51592
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NCBI登录号
- NP_056990
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UniProt
- Q9UPN9
抗原
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