At least two isoforms of IL-15 are known to exist.
纯化方法
IL-15 Antibody is affinity chromatography purified via peptide column.
免疫原
Rabbit polyclonal IL-15 antibody was raised against a 13 amino acid peptide near the center of human IL-15. The immunogen is located within amino acids 50 - 100 of IL-15.
IL-15 antibody can be used for detection of IL-15 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
IL-15 Antibody is supplied in PBS containing 0.02 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C,4 °C
储存方法
IL-15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
抗原
IL-15 (IL15)
(Interleukin 15 (IL15))
别名
IL-15
背景
IL-15 Antibody: Interleukin 15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.