CBX4 抗体 (N-Term)
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北京 101111
Quick Overview for CBX4 抗体 (N-Term) (ABIN6991741)
抗原
See all CBX4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 50-100, N-Term
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特异性
- Two alternatively spliced transcript variants have been observed.
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纯化方法
- CBX4 Antibody is affinity chromatography purified via peptide column.
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免疫原
- CBX4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CBX4. The immunogen is located within amino acids 50 - 100 of CBX4.
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亚型
- IgG
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应用备注
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CBX4 antibody can be used for detection of CBX4 by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- CBX4 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- CBX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- CBX4 (Chromobox Homolog 4 (CBX4))
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别名
- CBX4
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背景
- CBX4 Antibody: Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
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分子量
- 62 kDa
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基因ID
- 8535
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NCBI登录号
- NP_003646
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UniProt
- O00257
抗原
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