VASH1 抗体 (C-Term)
Quick Overview for VASH1 抗体 (C-Term) (ABIN6991536)
抗原
See all VASH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 290-340, C-Term
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特异性
- VASH1 antibody is predicted to not cross-react with other vasohibin protein family members. At least two isoforms are known to exist, this antibody will recognize only the long isoform.
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纯化方法
- VASH1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- VASH1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human VASH1. The immunogen is located within amino acids 290 - 340 of VASH1.
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亚型
- IgG
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应用备注
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VASH1 antibody can be used for detection of VASH1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- VASH1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- VASH1 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- VASH1 (Vasohibin 1 (VASH1))
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别名
- VASH1
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背景
- VASH1 Antibody: VASH1 was originally identified as an endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor that acts in a negative feedback manner. VASH1 mRNA is expressed brain, heart, kidney and placenta in the adult, with robust expression in various organs during embryonic development. VASH1 expression in tumor cells and tumor vasculature is silenced by methylation by increased expression of Zeste homolog 2 (EZH2). The increase of EZH2 expression is induced by VEGF stimulation, leading to poor clinical prognosis. Recombinant adenovirus expressing VASH prevented tumor angiogenesis and inhibited tumor growth, suggesting that it may be a potentially valuable antitumor therapy in the clinic.
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基因ID
- 22846
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NCBI登录号
- NP_055724
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UniProt
- Q7L8A9
抗原
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