IRF4 抗体 (C-Term)
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Quick Overview for IRF4 抗体 (C-Term) (ABIN6991531)
抗原
See all IRF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- IRF4 antibody is predicted to not cross-react with other IRF protein family members. IRF4 often migrates at a higher than predicted molecular weight in SDS-PAGE.
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纯化方法
- IRF4 Antibody is affinity chromatography purified via peptide column.
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免疫原
- IRF4 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human IRF4. The immunogen is located within the last 50 amino acids of IRF4.
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亚型
- IgG
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应用备注
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IRF4 antibody can be used for detection of IRF4 by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- IRF4 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- IRF4 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- IRF4 (Interferon Regulatory Factor 4 (IRF4))
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别名
- IRF4
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背景
- IRF4 Antibody: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Another member, IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF4 expression is tightly regulated in resting primary T cells and plays an essential role in the homeostasis and function of mature lymphocytes. IRF4 is induced by Toll-like receptor (TLR) activation and acts as a negative regulator of TLR signaling.
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基因ID
- 3662
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NCBI登录号
- NP_002451
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UniProt
- Q15306
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途径
- Chromatin Binding
抗原
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