SCUBE3 抗体 (AA 440-490)
Quick Overview for SCUBE3 抗体 (AA 440-490) (ABIN6991375)
抗原
See all SCUBE3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 440-490
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纯化方法
- SCUBE3 Antibody is affinity chromatography purified via peptide column.
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免疫原
- SCUBE3 antibody was raised against a 15 amino acid peptide near the center of human SCUBE3. The immunogen is located within amino acids 440 - 490 of SCUBE3.
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亚型
- IgG
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anti-Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3) (AA 401-499) antibody
SCUBE3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3) (AA 29-147) antibodySCUBE3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3) (AA 807-993) antibodySCUBE3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3) (AA 480-509) antibodySCUBE3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB39797 unconjugated
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应用备注
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SCUBE3 antibody can be used for detection of SCUBE3 by immunohistochemistry at 5 μ,g/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- SCUBE3 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- SCUBE3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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- SCUBE3 (Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3))
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别名
- SCUBE3
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背景
- SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart (1,2). Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Snail, and Slug.
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分子量
- Predicted: 109 kDa
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基因ID
- 222663
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NCBI登录号
- NP_689966
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UniProt
- Q8IX30
抗原
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