TCTN1 抗体 (N-Term)
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北京 101111
Quick Overview for TCTN1 抗体 (N-Term) (ABIN6991369)
抗原
See all TCTN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-80, N-Term
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纯化方法
- TCTN1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- TCTN1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TCTN1. The immunogen is located within amino acids 30 - 80 of TCTN1.
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亚型
- IgG
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应用备注
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TCTN1 antibody can be used for detection of TCTN1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TCTN1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TCTN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TCTN1 (Tectonic Family Member 1 (TCTN1))
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别名
- TCTN1
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背景
- TCTN1 Antibody: TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
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基因ID
- 79600
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NCBI登录号
- NP_001076007
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UniProt
- Q2MV58
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途径
- Tube Formation
抗原
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