TMEM38A 抗体 (C-Term)
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北京 101111
Quick Overview for TMEM38A 抗体 (C-Term) (ABIN6991239)
抗原
See all TMEM38A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- TMEM38A Antibody is affinity chromatography purified via peptide column.
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免疫原
- TMEM38A antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38A. The immunogen is located within the last 50 amino acids of TMEM38A.
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亚型
- IgG
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应用备注
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TMEM38A antibody can be used for detection of TMEM38A by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- TMEM38A Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- TMEM38A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- TMEM38A (Transmembrane Protein 38A (TMEM38A))
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别名
- TMEM38A
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背景
- TMEM38A Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
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基因ID
- 79041
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UniProt
- Q9H6F2
抗原
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