INSM1 抗体 (N-Term)
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Quick Overview for INSM1 抗体 (N-Term) (ABIN6991197)
抗原
See all INSM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 90-140, N-Term
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纯化方法
- IA-1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- IA-1 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human IA-1. The immunogen is located within amino acids 90 - 140 of IA-1.
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亚型
- IgG
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应用备注
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IA-1 antibody can be used for detection of IA-1 by Western blot at 1 μ,g/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- IA-1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- IA-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- INSM1 (Insulinoma-Associated 1 (INSM1))
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别名
- IA-1
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背景
- IA-1 Antibody: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100 % of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
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基因ID
- 3642
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NCBI登录号
- NP_002187
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UniProt
- Q01101
抗原
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