FAM33A 抗体 (N-Term)
Quick Overview for FAM33A 抗体 (N-Term) (ABIN6991191)
抗原
See all FAM33A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- SKA2 Antibody is affinity chromatography purified via peptide column.
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免疫原
- SKA2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human SKA2. The immunogen is located within the first 50 amino acids of SKA2.
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亚型
- IgG
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anti-Spindle and Kinetochore-Associated Protein 2 (FAM33A) (AA 1-121) antibody
FAM33A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Spindle and Kinetochore-Associated Protein 2 (FAM33A) (N-Term) antibodyFAM33A 适用: 人, 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Spindle and Kinetochore-Associated Protein 2 (FAM33A) (AA 9-37), (N-Term) antibodyFAM33A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB31468 unconjugated
anti-Spindle and Kinetochore-Associated Protein 2 (FAM33A) (AA 16-45), (N-Term) antibodyFAM33A 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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SKA2 antibody can be used for detection of SKA2 by Western blot at 0.5 - 1 μ,g/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- SKA2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- SKA2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))
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别名
- SKA2
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背景
- SKA2 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.
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基因ID
- 348235
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NCBI登录号
- NP_872426
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UniProt
- Q8WVK7
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途径
- M Phase
抗原
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