NOTUM 抗体 (N-Term)
Quick Overview for NOTUM 抗体 (N-Term) (ABIN6991166)
抗原
See all NOTUM 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 90-140, N-Term
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纯化方法
- NOTUM Antibody is affinity chromatography purified via peptide column.
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免疫原
- NOTUM antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human NOTUM. The immunogen is located within amino acids 90 - 140 of NOTUM.
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亚型
- IgG
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anti-Notum Pectinacetylesterase Homolog (NOTUM) (AA 100-235) antibody
NOTUM 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Notum Pectinacetylesterase Homolog (NOTUM) (AA 20-320) antibodyNOTUM 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Notum Pectinacetylesterase Homolog (NOTUM) (N-Term) antibodyNOTUM 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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NOTUM antibody can be used for detection of NOTUM by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- NOTUM Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- NOTUM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
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别名
- NOTUM
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背景
- NOTUM Antibody: In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by beta-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
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基因ID
- 147111
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NCBI登录号
- NP_848588
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UniProt
- Q6P988
抗原
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