THEM4 抗体 (AA 60-110)
The 兔 多克隆 anti-THEM4 antibody is suitable to detect THEM4 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, ELISA, IF 和 IHC (p).
产品编号 ABIN6991139
发货至:
中国
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中国
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北京 101111
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Quick Overview for THEM4 抗体 (AA 60-110) (ABIN6991139)
抗原
See all THEM4 抗体
THEM4
(Thioesterase Superfamily Member 4 (THEM4))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This THEM4 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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抗原表位
- AA 60-110
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特异性
- The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4.
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纯化方法
- THEM4 Antibody is affinity chromatography purified via peptide column.
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免疫原
- THEM4 antibody was raised against an 18 amino acid synthetic peptide near the center of human THEM4. The immunogen is located within amino acids 60 - 110 of THEM4.
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亚型
- IgG
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anti-Thioesterase Superfamily Member 4 (THEM4) (AA 1-240) antibody
THEM4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Thioesterase Superfamily Member 4 (THEM4) (Center) antibodyTHEM4 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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THEM4 antibody can be used for detection of THEM4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- THEM4 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- THEM4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- THEM4 (Thioesterase Superfamily Member 4 (THEM4))
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别名
- THEM4
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背景
- THEM4 Antibody: THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
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基因ID
- 117145
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NCBI登录号
- NP_444283
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UniProt
- Q5T1C6
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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