AFAP1L2 抗体 (C-Term)
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北京 101111
Quick Overview for AFAP1L2 抗体 (C-Term) (ABIN6991136)
抗原
See all AFAP1L2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- AFAP1L2 Antibody is affinity chromatography purified via peptide column.
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免疫原
- AFAP1L2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human AFAP1L2. The immunogen is located within the last 50 amino acids of AFAP1L2.
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亚型
- IgG
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anti-Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (AA 674-818) antibody
AFAP1L2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2H6D1 unconjugated
anti-Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (AA 66-115) antibodyAFAP1L2 适用: 人, 小鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (N-Term) antibodyAFAP1L2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (C-Term) antibodyAFAP1L2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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AFAP1L2 antibody can be used for detection of AFAP1L2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- AFAP1L2 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- AFAP1L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- AFAP1L2 (Actin Filament Associated Protein 1-Like 2 (AFAP1L2))
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别名
- AFAP1L2
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背景
- AFAP1L2 Antibody: AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.
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基因ID
- 84632
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NCBI登录号
- NP_001001936
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UniProt
- Q8N4X5
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途径
- EGFR Signaling Pathway
抗原
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