MACC1 抗体 (AA 430-480)
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北京 101111
Quick Overview for MACC1 抗体 (AA 430-480) (ABIN6991128)
抗原
See all MACC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 430-480
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特异性
- At least two isoforms of MACC1 are known to exist.
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纯化方法
- MACC1 Antibody is affinity chromatography purified via peptide column.
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免疫原
- MACC1 antibody was raised against a 17 amino acid synthetic peptide near the center of human MACC1. The immunogen is located within amino acids 430 - 480 of MACC1.
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亚型
- IgG
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anti-Metastasis Associated in Colon Cancer 1 (MACC1) (AA 761-852) antibody
MACC1 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated in Colon Cancer 1 (MACC1) (AA 371-514) antibodyMACC1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated in Colon Cancer 1 (MACC1) (AA 522-784) antibodyMACC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated in Colon Cancer 1 (MACC1) (AA 522-784) antibodyMACC1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D4 unconjugated
anti-Metastasis Associated in Colon Cancer 1 (MACC1) (Center) antibodyMACC1 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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MACC1 antibody can be used for detection of MACC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- MACC1 Antibody is supplied in PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,4 °C
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储存方法
- MACC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))
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别名
- MACC1
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背景
- MACC1 Antibody: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.
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分子量
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Predicted: 94 kDa
Observed: 90 kDa -
基因ID
- 346389
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NCBI登录号
- NP_877439
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UniProt
- Q6ZN28
抗原
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