RNF168 抗体 (C-Term)
Quick Overview for RNF168 抗体 (C-Term) (ABIN6991108)
抗原
See all RNF168 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 440-490, C-Term
-
纯化方法
- RNF168 Antibody is affinity chromatography purified via peptide column.
-
免疫原
- RNF168 antibody was raised against an 18 amino acid synthetic peptide from near the carboxy terminus of human RNF168. The immunogen is located within amino acids 440 - 490 of RNF168.
-
亚型
- IgG
-
-
anti-Ring Finger Protein 168 (RNF168) (AA 462-571) antibody
RNF168 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E1 unconjugated
anti-Ring Finger Protein 168 (RNF168) (C-Term) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 1-571) antibodyRNF168 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 1-571) antibodyRNF168 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 401-450) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠, 豚鼠, 兔, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (C-Term) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠, 豚鼠, 兔, Cow, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 194-296) antibodyRNF168 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 300-571) antibodyRNF168 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (C-Term) antibodyRNF168 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
RNF168 antibody can be used for detection of RNF168 by Western blot at 1 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- RNF168 Antibody is supplied in PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,4 °C
-
储存方法
- RNF168 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
-
-
- RNF168 (Ring Finger Protein 168 (RNF168))
-
别名
- RNF168
-
背景
- RNF168 Antibody: RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance. At least three isoforms of RNF168 are known to exist.
-
基因ID
- 165918
-
NCBI登录号
- NP_689830
-
UniProt
- Q8IYW5
-
途径
- Production of Molecular Mediator of Immune Response
抗原
-
