SPG11 抗体 (C-Term)
SPG11
适用: 人, 小鼠, 大鼠
ELISA, WB, IHC (p)
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all SPG11 抗体
- SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))
- 抗原表位
- AA 2360-2410, C-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SPG11 antibody is un-conjugated
- 应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- SPG11 Antibody is affinity chromatography purified via peptide column.
- 免疫原
- SPG11 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SPG11. The immunogen is located within amino acids 2360 - 2410 of SPG11.
- 亚型
- IgG
- Top Product
- Discover our top product SPG11 Primary Antibody
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anti-Spastic Paraplegia 11 (Autosomal Recessive) (SPG11) (AA 2019-2318) antibody
SPG11 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Spastic Paraplegia 11 (Autosomal Recessive) (SPG11) (AA 1-425) antibodySPG11 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
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SPG11 antibody can be used for detection of SPG11 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- SPG11 Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- SPG11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))
- 别名
- SPG11 (SPG11 产品)
- 别名
- 6030465E24Rik antibody, A330015I11 antibody, C530005A01Rik antibody, KIAA1840 antibody, RGD1562529 antibody, SPG11, spatacsin vesicle trafficking associated antibody, Spg11 antibody, SPG11 antibody
- 背景
- SPG11 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders. Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene. Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.
- 基因ID
- 80208
- UniProt
- Q96JI7
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